Research projects
As a result of the 2010 mini grant program, the IBD Research Foundation reached an agreement upon funding the following research projects:
Dr. Jessica Mwinyi
Division of Clinical Pharmacology and Toxicology
Project: Analysis of PPAR-γ haplotype structure and its influence on disease susceptibility, pathogenesis and activity of inflammatory bowel disease
Aim: to comprehensively determine PPAR-γ gene variants by sequencing all seven NR1C3 exons which code for the most common PPAR-γ splice variant PPAR-γ2 and the first 50 bp of the neighbouring intronic regions in 300 IBD patients and compare the sequencing outcome with the sequencing results obtained in 200 non-IBD subjects.
Stefania Vetrano, Bsc
Laboratory of Immunology and Inflammation
Istituto Clinico Humanitas,
Project: The protein C pathway: a novel mediator in intestinal homeostasis in IBD
Aims:
- Study the expression and function of the protein C pathway in human IBD
- Investigate the functional role of the protein C pathway in mediating epithelial homeostasis in a dendritic cell-dependent manner
Prof. Giulio G. Muccioli, PhD
Bioanalysis and Pharmacology of Bioactive Lipids lab
Université catholique de Louvain, Belgium
Project: Exploring the potential of N-palmitoylethanolamine in a mouse model of inflammatory bowel diseases
Aim: To study the potential anti-inflammatory properties of PEA in an animal model of colitis, in treating colon inflammation as well as the colitis-related LPS induced systemic inflammation