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The way ahead

According to Rod Mitchell, chairman of the IBD Research Foundation, it's just a matter of time before finding a cure but more funds are needed for vital research

Research projects

As a result of the 2010 mini grant program, the IBD Research Foundation reached an agreement upon funding the following research projects:

 

Dr. Jessica Mwinyi

Division of Clinical Pharmacology and Toxicology

UniversitätsSpital Zürich, Switzerland

Project: Analysis of PPAR-γ haplotype structure and its influence on disease susceptibility, pathogenesis and activity of inflammatory bowel disease

Aim: to comprehensively determine PPAR-γ gene variants by sequencing all seven NR1C3 exons which code for the most common PPAR-γ splice variant PPAR-γ2 and the first 50 bp of the neighbouring intronic regions in 300 IBD patients and compare the sequencing outcome with the sequencing results obtained in 200 non-IBD subjects.

 

 

Stefania Vetrano, Bsc

Laboratory of Immunology and Inflammation

Istituto Clinico Humanitas, Rozzano, Italy

Project: The protein C pathway: a novel mediator in intestinal homeostasis in IBD

Aims:

  1. Study the expression and function of the protein C pathway in human IBD
  2. Investigate the functional role of the protein C pathway in mediating epithelial homeostasis in a dendritic cell-dependent manner

 

Prof. Giulio G. Muccioli, PhD

Bioanalysis and Pharmacology of Bioactive Lipids lab

Université catholique de Louvain, Belgium

Project: Exploring the potential of N-palmitoylethanolamine in a mouse model of inflammatory bowel diseases

Aim: To study the potential anti-inflammatory properties of PEA in an animal model of colitis, in treating colon inflammation as well as the colitis-related LPS induced systemic inflammation